The Difference Between Serum and Plasma

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Serum and Plasma

When it comes to blood, there is a huge difference between serum and plasma. It is important to know the difference between the two before running any tests.

The liquid component of the blood, plasma contains clotting factors and fibrinogen. It also contains nutrients, electrolytes, and antibodies.


Blood is a clear, yellow liquid that contains red and white blood cells, oxygen, nutrients, proteins, hormones, enzymes, minerals, fatty acids, gases, fibrinogen, clotting factors, and other substances. This liquid is essential to the functioning of the body and helps in preventing excessive bleeding following injury.

During blood flow, the blood separates into two parts: serum and plasma. Serum is the water component of the blood that clots and plasma is the liquid portion of blood that does not clot.


When whole blood clots, it is collected and separated in a tube that is treated with an anticoagulant such as EDTA, sodium citrate, or heparin to prevent the blood from clotting. The clot is then removed by centrifugation, leaving the supernatant, which is the liquid part of the blood.

A clot can break away from the spot where it formed and travel to other areas of the body, such as the heart or lungs, where it can be dangerous and even deadly. Blood clots can also block or reduce the amount of blood that reaches vital organs, such as the brain or kidneys, and cause an episode of shock.

Blood clotting disorders can be inherited or acquired. Identifying an underlying clotting disorder can help you get the correct treatment to prevent future clots from forming.

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Clotting disorders can affect any organ in the body. They are usually preventable if you manage your risk factors, such as smoking, high blood pressure, obesity, diabetes, and certain medications.

You should seek medical attention for any bleeding problems you may have, such as bruising, swelling, or blood in your stool. You can also talk to your doctor about any medications you are taking or a family history of blood clotting disorders.

You should be tested for a blood clotting disorder as soon as you suspect it. Your doctor will determine the right type of medication and length of treatment for you. You can also participate in a clinical trial, which may offer access to novel therapies that treat your underlying clotting disorder.


Coagulation refers to the ability of your body to form blood clots, which help keep bleeding at bay. It is an important natural process that your body uses to prevent injury, but it can also cause problems if you have a coagulation disorder.

There are many ways to test for a coagulation disorder. A doctor will ask about your symptoms and family history to determine if you have any clotting issues. They may also take a physical exam to identify any bruising or swelling.

They may also recommend a coagulation study to find out whether your clotting factors are working properly. This can help diagnose a coagulation disorder and identify the best treatment.

During the coagulation process, your blood cells and proteins interact with each other to form a clot that seals your body together. This helps your blood to carry nutrients and oxygen throughout your body and reduces the risk of excessive bleeding.

Your body uses a complex series of chemicals called clotting factors to help your blood clot safely and effectively. There are 13 principal coagulation factors that are classified as a Roman numeral from I to XIII, and each clotting factor is responsible for activating different pathways of coagulation.

These factors work in conjunction with a protein called fibrinogen to help clot blood. The two factors work in an overlapping pathway, so even if one coagulation factor is missing, the other can still help your blood clot.

The coagulation process can be interrupted by certain medications, including anticoagulants (blood thinners). They are designed to block the action of clotting factors and prevent your blood from forming blood clots.

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A coagulation disorder can result in a high concentration of one or more clotting factors, or a low concentration of all clotting factors. A coagulation test can show which clotting factors are missing and whether the problem is hereditary or caused by another health condition.

The coagulation process is complicated, and it is difficult to know exactly how much of each clotting factor you have in your blood. The blood-clotting studies can tell you how many clotting factors your body has, but it is impossible to tell exactly what percentage of the 13 clotting factors your blood contains without more extensive tests.


A blood test that measures the concentration of electrolytes, such as sodium, potassium, chloride, and bicarbonate, is a vital tool for diagnosing medical problems. These tests also can help monitor the effects of medicines.

Almost 55% of the total volume of blood is plasma, which is a straw-colored liquid. It is made up of water, proteins, enzymes, clotting factors, salts, vitamins, hormones, and other substances. It also contains antibodies that fight diseases and infections.

Serum is another liquid component of the blood. It is made up of main water, but it also contains proteins, electrolytes, and antibodies.

It also contains other molecules that are not found in plasma. These include blood cells, clotting factors, and other molecules that help the body fight disease.

There is some confusion between serum and plasma, but they are actually two different types of fluid in the blood. The main difference between these fluids is that plasma contains clotting factors while serum does not.

The other major difference is that plasma contains a lot of liquid, whereas serum is mostly solids. This means that serum is more important for blood transfusions than plasma.

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This is why it is important to know the differences between these two fluids. Knowing the difference between them can help you to make a more informed decision about which test you should take.

Electrolyte levels in the blood are an essential part of hydration and how the body functions. They also affect your heartbeat and blood pressure.

When the body is healthy, most electrolytes are in a normal range. But if these levels are too low or too high, it could lead to serious conditions and problems.

Symptoms of an electrolyte imbalance can be similar to those of other health problems, and they may include nausea and vomiting, fatigue, confusion, or tingling in the hands and feet. In addition, it can also cause breathing problems.

Electrolyte levels are affected by many factors, including diet and a person’s lifestyle. The best way to keep your electrolyte levels in a healthy range is to drink plenty of water, eat nutritious foods, and avoid alcohol, caffeine, tobacco, and other toxins.

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Blood is the body’s fluid connective tissue that transports nutrients and oxygen, as well as waste products. It also regulates the body’s pH level and temperature through interactions with acids and bases.

Red blood cells carry oxygen; white blood cells are immune system cells that fight infections and help with the body’s immunity. Plasma is the liquid part of blood and accounts for around 55% of the total volume. It consists of 90% water and 8% solids including proteins, electrolytes, antibodies, nutrients, and waste products.

Proteins make up around half of the plasma, with globulins and albumin making up the other half. These proteins are important for maintaining osmotic pressures and transporting hormones and fatty acids throughout the body.

The other components of plasma are a variety of organic molecules that help to transport substances from one part of the body to another. These include sugars (e.g. glucose), mineral salts, and a number of amino acids. These amino acids are derived from various foods and from the absorption of proteins in the intestinal tract, among other sources.

Some of these amino acids are broken down into urea, which has a concentration of about 4.2 mmol/L. Other amino acids are used to make nitric oxide, which is involved in the formation of red blood cells and plays a role in blood pressure regulation.

A soluble protein in plasma is fibrinogen, which can bind with other blood proteins to form a clot or thrombus. This clot can be either white or red, depending on the composition of the clot and whether it contains platelets.

Serum, on the other hand, consists of blood plasma that has been removed from the clotting factors. This means that serum contains proteins, antibodies, electrolytes, and other compounds that do not participate in blood clotting.

It is also possible to separate plasma from the blood by artificially spinning or centrifuging the blood, but this can be costly and time-consuming. Hence, the serum is preferred for blood typing experiments and for diagnostic testing.

In addition, serum and plasma contain antibodies, which can be used to develop countermeasures against a certain pathogen or poison. This can be useful for preventing illnesses, as well as for treating bites and stings from venomous animals.

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